Background: Peptic ulcer disease (PUD) is a frequent outpatient diagnosis. Although medications and precautions have advanced to control this disease, the prevalence of PUD remains high. The complication of perforated peptic ulcer disease (PPUD) is the most common reason for urgent PUD surgery. Therefore, it is critical to determine the risk factors for developing a postoperative leak. Objectives: This study aims to identify the risk factors for gastrointestinal leak after operative repair of PPUD to guide for appropriate intraoperative decisions and postoperative care. Patients and Methods: This is a retrospective cohort study of 60 patients who had PPUD surgically repaired at a tertiary medical facility. The possible risk factors for postoperative leak development were recorded. Age, sex, BMI, preoperative usage of steroids, preoperative usage of tobacco, comorbidities, vital signs at admission, preoperative albumin, preoperative complete blood count, and perforation size were among the risk factors that were investigated. Results: In this study, the leak occurred among six (10%) patients, and a burst abdomen among four (5%) patients, while 50 (85%) patients did not develop postoperative complications. Our results revealed that the risk factors after repair of PPUD include older age (56.33±15.9 years), higher BMI (35.9±16.7 kg/m2), tobacco use, presence of comorbidities (Chronic obstructive pulmonary disease, diabetes mellitus, hypertension, and liver cirrhosis), and larger size of perforation at 3±3 cm. Conclusion: The study demonstrated that older age, higher BMI, tobacco use, the presence of comorbidities, and a larger size of perforation are risk factors for the development of leaks after operative repair of PPUD.
Ragab, A., Said, S., Ebrahim, B., Khattab, M., & Mohey, H. (2025). Risk Factors for Gastrointestinal Leak after Operative Repair of Perforated Peptic Ulcer Disease. The Egyptian Journal of Surgery, 44(2), 562-568. doi: 10.21608/ejsur.2024.326081.1222
MLA
Amr A. Ragab; Sami M. Said; Badr E. Ebrahim; Mohamed H. Khattab; Hytham H. Mohey. "Risk Factors for Gastrointestinal Leak after Operative Repair of Perforated Peptic Ulcer Disease", The Egyptian Journal of Surgery, 44, 2, 2025, 562-568. doi: 10.21608/ejsur.2024.326081.1222
HARVARD
Ragab, A., Said, S., Ebrahim, B., Khattab, M., Mohey, H. (2025). 'Risk Factors for Gastrointestinal Leak after Operative Repair of Perforated Peptic Ulcer Disease', The Egyptian Journal of Surgery, 44(2), pp. 562-568. doi: 10.21608/ejsur.2024.326081.1222
VANCOUVER
Ragab, A., Said, S., Ebrahim, B., Khattab, M., Mohey, H. Risk Factors for Gastrointestinal Leak after Operative Repair of Perforated Peptic Ulcer Disease. The Egyptian Journal of Surgery, 2025; 44(2): 562-568. doi: 10.21608/ejsur.2024.326081.1222
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