RESULTS OF MANAGEMENT OF COLORECTAL CARCINOMA

Document Type : Original Article

Authors

1 Surgery, South Valley University

2 Radiotherapy and Microbiology, South Valley University

3 Immunology Departments, South Valley University

4 Pathology Department, Assiut Faculty of Medicine. Egypt.

Abstract

Background: Colorectal cancer is the only commonly curable visceral malignancy constituting a significant problem as 
its outcome has remained poor and nearly unchanged over the last 25 years. This study has been performed to outline results of management of colorectal carcinoma. 
Patients and Methods: 78 patients with colorectal carcinoma included in this study with Dukes’A, B and C stages. 
Investigations, surgical treatment and histopathological studies were carried out. Adjuvant treatment was adopted in 
selected cases. Carcinoembryonic antigen estimation was performed. Follow-up in only 73 patients was carried out, who 
passed the postoperative period (4 weeks). Patterns of relapse and overall survival were outlined in follow-up cases for 42 months. 
Results: Relapse was encountered in 45.2% of patients. Most patients with Dukes’C had relapse (79.3%) and to less 
extent those with Dukes’B (23.5%). 42.9% of rectal carcinoma showed local relapse and 25% of colonic carcinoma showed local relapse. 87.5% of patients with mucinous carcinoma showed relapse and only 33.3% of non-mucinous carcinoma 
showed relapse. Overall survival was 51% at 42 months according to the Kaplan-Meier method. Patients with Dukes’A had the best survival rate (80%), followed by Dukes’B (64%) and Dukes’C (27%). Dukes’ stages, type of pathology and relapse of tumor had a statistically significant difference on overall survival. 
Conclusion: This study outlined results of management of colorectal carcinoma and guidelines of surgical and adjuvant 
treatment. 

Keywords

The Egyptian Journal of Surgery
Volume 20, Issue 2
April 2001
Pages 529-540

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