PROGNOSTIC SIGNIFICANCE OF BCL-2, BAX AND P53 EXPRESSION IN BREAST CANCER

Document Type : Original Article

Authors

1 General Surgery Department, Al-Mansoura Faculty of Medicine, Egypt

2 Pathology Department, Al-Mansoura Faculty of Medicine, Egypt

Abstract

Aim: of this study was to investigate the significance of apoptosis-related genes bcl-2 and Bax in breast carcinoma cases 
treated with radical surgery plus radiotherapy and adjuvant chemotherapy for at least 1 year and their relation with 
expression of p53. 
Methods: After surgical resection immunohistochemistry was performed to determine Bcl-2, Bax, p53 and estrogen receptor (ER) expression in paraffin-embedded tissues of 50 invasive breast cancers.And overall survival was assessed. 
Results: Bcl-2, Bax, P53 and ER immunostaining displayed a positive relation with increasing histologic grade (P=0.000) and negative relation with the staging .Bcl2 displayed a negative relation with p53 (P=0.035) and a positive relation with Bax and ER (P= 0.003 and P= 0.011 respectively). Expression of Bcl2 was associated significant improvement in overall survival (p=o.o1). 
Conclusion: regulation of apoptosis is important in invasive ductal carcinoma. These results indicate that bcl-2 expression is significantly associated with hormonal receptor status so it is good prognostic marker, and that p53 is a significant 
prognostic marker. No significant relation between Bax and overall survival in relation to the stage, p53 or ER.

Keywords

The Egyptian Journal of Surgery
Volume 25, Issue 4
October 2006
Pages 213-220

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