Aim: Helicobacter pylori (H.Pylori) plays a fundamental role in the causation of duodenal ulcer. This study was conducted to elucidate the prevalence of H.Pylori in patients with a perforated duodenal ulcer and to determine whether eradication of H.Pylori prevent ulcer recurrence following simple repair of the perforation. Methods: Eighty three patients admitted with perforated duodenal ulcer, only seventy seven patients treated with simple closure included in our study. Sixty five patients (84.4 %) who had H.Pylori infection were randomly divided into triple therapy group (34 patients) and alone group (31 patients). Follow up endoscopy was performed at 8 w, 16 w and 1 year to show the ulcer healing and determine H.Pylori. Results: The eradication of H.Pylori was significantly higher in triple therapy group than omeprazole alone group (at 8 weeks 91.2% vs. 22.6% respectively). Initial healing of ulcer was significantly better in eradication group and after one year the difference in ulcer recurrence between the two groups was statistically significant (2 (6.1%) in eradication group vs. 8 (29.6%) in omeprazole alone group P=0.001). Conclusion: H.Pylori was present at a high ratio in patients with duodenal ulcer perforation. Eradication of H.Pylori after simple closure of a perforated duodenal ulcer reduces the incidence of recurrent ulcer.
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., & Sherief, D. (2007). EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER. The Egyptian Journal of Surgery, 26(2), 75-80. doi: 10.21608/ejsur.2007.372322
MLA
Ayman El-Nakeeb; Amir Fikry; Tito Mitwally; ELYamani Fouda; Saleh El-Awadi; Hisham Abd El-Menem; Hosam Ghazy; Mohamed Farid; Doaa Sherief. "EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER", The Egyptian Journal of Surgery, 26, 2, 2007, 75-80. doi: 10.21608/ejsur.2007.372322
HARVARD
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., Sherief, D. (2007). 'EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER', The Egyptian Journal of Surgery, 26(2), pp. 75-80. doi: 10.21608/ejsur.2007.372322
VANCOUVER
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., Sherief, D. EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER. The Egyptian Journal of Surgery, 2007; 26(2): 75-80. doi: 10.21608/ejsur.2007.372322
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