FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME

Document Type : Original Article

Authors

1 Surgery, Mansoura University Hospital, Egypt

2 Mansoura General Hospital

3 Clinical Pathology, Mansoura University Hospital, Egypt

Abstract

Aim: Identify Fournier’s disease associations, outcome and survival factors. 
Methods: Fournier’s gangrene patients (34) were treated between 2003 to 2006. Data were collected about medical history, physical findings, metabolic tests, bacteriologic typing, immunologic screening for T cell function, serum IL-2, ICAM-I and γIFN with their management. 
Results: The disease had age range 3 – 67 years, polymicrobial nature, and low serum albumin (3.3 ± 0.6 mg/dl). Inadequate Tcell function (18255.3 ± 1641 CPM) and high ICAM-I, IL-2, γIFN (10.5 ± 0.7, 93.3 ± 1.6, 131 ± 2 pg/ml) were detected in Fournier’s disease but serum IL-2 was relevant to outcome (P = 0.0001). The survival factors were patients’ age (P = 0.0001), presentation timing (P = 0.001), both disease extent (P = 0.0001),septic shock(P = 0.01),severe SIRS (P = 0.001), serum albumin(P = 0.0001) and IL-2. 
Conclusion: Fournier’s disease is consistent with deviated metabolic status and immunologic dissonance, inciting local 
gangrenous process, these parameters are significant for disease outcome.  

Keywords

Files

Share

How to cite

Statistics