ROLE OF STATINS IN PREVENTION OF INFECTION IN HERNIA MESH REPAIR; PROSPECTIVE STUDY

Document Type : Original Article

Authors

1 Department of Surgery, Alexandria Faculty of Medicine

2 Department of Anesthesia, Menofiya Faculty of Medicine, Egypt

Abstract

Background: There was good evidence suggests that statin may reduce the risk of infections and infectionrelated complications in all medical fields including surgery. Our objective was to assess the association 
between statin usage and risk of infections and related outcomes in inguinal hernia open mesh repair. 
Method: In this study, a total of 609 Egyptian patients, with different types of hernia underwent 
hernioplasty with mesh repair during period from May 2010 to April 2011. Review of their drug history 
divided them into two groups: Group A included 67 patients who were taken statin tablet regularly for at 
least 9 months and group B who included 542 patients with no drug intake. We documented any 
postoperative wound infection and compare between incidences of wound infection in the two groups. 
Results: In Group A, only 2 cases (2.9%) were found to have wound infection while in Group B, there were 
22 cases (4%) that were found to have wound infection postoperatively. A significant difference is present 
between the two groups. (ρ = 0.05).
Conclusions: Our results suggest that statin usage is associated with a beneficial effect in preventing 
postoperative wound infections in open mesh repair for hernias. 

Keywords

The Egyptian Journal of Surgery
Volume 31, Issue 1
January 2012
Pages 30-35

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