Endoscopic dilatation with and without mitomycin C local application in esophageal strictures in pediatric patients

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Abstract

Background
Esophageal stricture is an important health problem in pediatrics. It affects the patient health and quality of life negatively. The aim was to compare between endoscopic dilatation followed by mitomycin C local application and conventional endoscopic dilatation alone in outcome of treatment of pediatric patients with esophageal strictures.
Patients and methods
This prospective randomized controlled study was performed on 42 pediatric patients presented with dysphagia resulting from esophageal strictures. The patients were classified into two groups (21 patients in each): group A, where endoscopic dilatation was followed with local application of mitomycin C, and group B, where endoscopic dilatation alone was done.
Results
There was no significant difference between both groups in age, sex, etiology, and weight before dilatation. Weight after dilatation and weight gain showed significant increase in group A than B. There was significant decrease in number and duration of sessions with significant increase in the intervals between sessions in group A than B. There were no detected complications related to mitomycin C.
Conclusion
Mitomycin C local application following endoscopic dilatation in esophageal stricture improves the outcome in pediatric patients by decreasing the number of dilatation sessions and shortens the treatment period thus reaching earlier cure.

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