Comparative study between effect of topical sucralfate cream and glyceryl trinitrate cream on post haemorrhoidectomy pain and wound healing

Document Type : Original Article

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Department of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Abstract

Background: Haemorrhoidectomy is the treatment of choice for third- and fourth-degree haemorrhoids.
Haemorrhoidectomy is avoided by many patients because it is linked to severe pain after surgery.
Topical sucralfate cream hastens the healing of wounds and reduces discomfort following hemorrhoidal surgery. After a
haemorrhoidectomy, topical use of glyceryl trinitrate (GTN) can reduce spasm and postoperative pain; also, increase Ano
dermal blood flow, and accelerate the healing of the wound.
Patients and Methods: This prospective randomized control single-blinded study was conducted over a one-year
duration. In General Surgery Department, Mansoura Faculty of Medicine with the inclusion of 60 patients with third- and
fourth-degree piles who underwent conventional Milligan–Morgan haemorridectomy.
Three groups of 60 patients were randomly assigned to participate in the current study: group A (the control group):
included 20 patients who received a placebo (petrolatum cream). group B (the sucralfate group), group C (GTN cream
group).
The visual analogue scale (VAS 0–10) was used to assess postoperative pain on days 1, 7, and 14 following surgery and
wound healing was assessed after 28 days.
Results: There was no significant difference between the three study groups as regards demographic data, symptoms, and
the VAS score on the first postoperative day.
On the seventh and 14th day postoperative, respectively, the VAS score was statistically significantly lower in the GTN
group followed by the Sucralfate group and finally the control group (P<0.001). The duration for complete wound healing
and the duration to return to daily activities were statistically significantly shorter in the sucralfate group followed by the
GTN group.

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